Bioorganic & medicinal chemistry

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a carbamoyl linker

K Kokosza, J Balzarini, DG Piotrowska

Index: Kokosza, Kamil; Balzarini, Jan; Piotrowska, Dorota G. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1097 - 1108

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Citation Number: 14

Abstract

5-Arylcarbamoyl-2-methylisoxazolidin-3-yl-3-phosphonates have been synthesised from N- methyl-C-diethoxyphosphorylnitrone and N-arylacrylamides in good yields. cis-and trans- isoxazolidine phosphonates obtained herein were evaluated for activity against a broad range of DNA and RNA viruses. None of the compounds were endowed with antiviral activity at subtoxic concentrations. Isoxazolidines having phenyl substituted with halogen (Ar= 2-F ...