3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors

…, PA Renhowe, TG Gesner, JM Jansen, J Lin…

Index: McBride, Christopher M.; Renhowe, Paul A.; Gesner, Thomas G.; Jansen, Johanna M.; Lin, Julie; Ma, Sylvia; Zhou, Yasheen; Shafer, Cynthia M. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3789 - 3792

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Citation Number: 17

Abstract

The 3-benzimidazol-2-yl-1H-indazole scaffold was developed as an alternate scaffold for our receptor tyrosine kinase (RTK) inhibitor program. In exploring the SAR of this series, it was discovered that a subset of these compounds potently inhibit the enzyme c-ABL. The SAR of these compounds is described.