Synergistic Effect of Palladium and Copper Catalysts: Catalytic Cyclizative Dimerization of ortho??(1??Alkynyl) benzamides Leading to Axially Chiral 1, 3??Butadienes

…, C Jaccoud, Q Wang, J Zhu

Index: Yao, Bo; Jaccoud, Carole; Wang, Qian; Zhu, Jieping Chemistry - A European Journal, 2012 , vol. 18, # 19 p. 5864 - 5868

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Citation Number: 24

Abstract

Wacker oxidation.[3] In connection with our ongoing project on the development of Pd-and Cu-catalyzed domino [4] and multicomponent reactions,[5] we were interested in developing a novel dimerization strategy by combining the use of Pd and Cu catalysts. The underline principle is shown in reaction (2) in Scheme 1. We hypothesized that the introduction of both PdII and CuII salts into a solution of alkyne in the presence of a suitable nucleophile could ...