Journal of catalysis

Fundamental insights into the enantioselectivity of hydrogenations on cinchona-modified platinum and palladium

E Schmidt, C Bucher, G Santarossa, T Mallat…

Index: Schmidt, Erik; Bucher, Christoph; Santarossa, Gianluca; Mallat, Tamas; Gilmour, Ryan; Baiker, Alfons Journal of Catalysis, 2012 , vol. 289, p. 238 - 248

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Citation Number: 42

Abstract

The influence of the configuration at the C8 and C9 positions of cinchona alkaloids was investigated by comparing the efficiency of cinchonidine, cinchonine, and 9-epi- cinchonidine as chiral modifiers. In the hydrogenation of ketones (methyl benzoylformate, ketopantolactone, methylglyoxal dimethylacetal, 2, 2, 2-trifluoroacetophenone) on Pt, a change in the configuration at C9 did not affect the absolute configuration of the main ...