Indolizines carrying various substituents in positions 5–8 were obtained from readily available 2-(1 H-pyrrol-1-yl) nitriles and α, β-unsaturated ketones or aldehydes in a one-pot procedure. Michael addition of the deprotonated aminonitriles to the acceptors followed by acid-catalyzed electrophilic cyclization produces 5, 6-dihydroindolizine-5-carbonitriles. From these stable intermediates, substituted indolizines were obtained via base-induced ...
