Human N 6-Methyl-AMP/DAMP Aminohydrolase (Abacavir 5'-Monophosphate Deaminase) is Capable of Metabolizing N 6-Substituted Purine Acyclic Nucleoside …

…, I Votruba, R Shibata, B Han, X Liu…

Index: Schinkmanova, Marketa; Votruba, Ivan; Shibata, Riri; Han, Bin; Liu, Xiaohong; Cihlar, Tomas; Holy, Antonin Collection of Czechoslovak Chemical Communications, 2008 , vol. 73, # 2 p. 275 - 291

Full Text: HTML

Citation Number: 17

Abstract

Abstract Recombinant human abacavir monophosphate deaminase (hABC-MP deaminase) was compared with the recently described rat N 6-methyl-AMP (meAMP) aminohydrolase. hABC-MP deaminase, a 42 kDa polypeptide, exists predominantly as a monomer under non- denaturing conditions. Similar to the rat enzyme, hABC-MP deaminase efficiently catalyzes the hydrolytic deamination of natural substrates meAMP (5), N 6, N 6-dimethyl-AMP (13) ...