Helvetica Chimica Acta

An Efficient Synthesis of 3??(1H??Tetrazol??5??yl) coumarins (= 3??(1H??Tetrazol??5??yl)??2H??1??benzopyran??2??ones) via Domino Knoevenagel Condensation, Pinner …

ZN Tisseh, M Dabiri, A Bazgir

Index: Tisseh, Zeinab Noroozi; Dabiri, Minoo; Bazgir, Ayoob Helvetica Chimica Acta, 2012 , vol. 95, # 9 p. 1600 - 1604

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Citation Number: 6

Abstract

Abstract A novel straightforward synthesis of 3-(1H-tetrazol-5-yl) coumarins (= 3-(1H-tetrazol- 5-yl)-2H-1-benzopyran-2-ones) 6 via domino Knoevenagel condensation, Pinner reaction, and 1, 3-dipolar cycloaddition of substituted salicylaldehydes (= 2-hydroxybenzaldehydes), malononitrile (propanedinitrile), and sodium azide in H 2 O is reported (Scheme 1 and Table 2). This general protocol provides a wide variety of 3-(1H-tetrazol-5-yl) coumarins in good ...