Tetrahedron

Total synthesis of palmyrolide A and its 5, 7-epi isomers

G Sudhakar, KJ Reddy, JB Nanubolu

Index: Sudhakar, Gangarajula; Reddy, Karla Janardhan; Nanubolu, Jagadeesh Babu Tetrahedron, 2013 , vol. 69, # 11 p. 2419 - 2429

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Citation Number: 18

Abstract

Stereoselective total synthesis of palmyrolide A, a 15-membered neuroactive macrolide, was described by adopting a synthetic strategy developed for the proposed structures, and its 5, 7-epi isomers. The strategy was designed in such a way that the set of stereoisomers, which were needed for establishing the absolute configuration of palmyrolide A, could be obtained from one time operation. The diastereoselective hydrogenation of exo-methylene-γ- ...

~92%

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