… on Regioselectivity in the Nucleophilic Aromatic Substitution Reaction of 3??Substituted 2, 6??Dichloropyridines with 1??Methylpiperazine Studied by a Chemical Design …

…, M Marczynke, F Giordanetto

Index: Bach, Peter; Marczynke, Michaela; Giordanetto, Fabrizio European Journal of Organic Chemistry, 2012 , # 35 p. 6940 - 6952

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Abstract

Abstract A chemical design strategy has been used to select 3-substituted 2, 6- dichloropyridines for the nucleophilic aromatic substitution reaction with 1-methylpiperazine. The aim was to study the dependency of the regioselectivity in these reactions on the character of the pyridine 3-substituent expressed by their lipophilicity (PI), size (MR), and inductive effect (σ p). Interestingly, the regioselectivity did not correlate with any of these ...