Chemistry Letters

USE OF 3, 4-DIMETHOXYBENZYL GROUP AS A PROTECTING GROUP FOR THE 2′-HYDROXYL GROUP IN THE SYNTHESIS OF OLIGORIBONUCLEOTIDES

H Takaku, T Ito, K Imai

Index: Takaku, Hiroshi; Ito, Tsunehiko; Imai, Kazuaki Chemistry Letters, 1986 , p. 1005 - 1008

Full Text: HTML

Citation Number: 11

Abstract

The 3, 4-dimethoxybenzyl group was introduced to the 2′-hydroxyl group by the reaction of nucleosides with 3, 4-dimethoxybenzyl trichloroacetimidate or 3, 4-dimethoxybenzyl bromide-NaH. Further, this group can be used as a protecting group for the O 6-amide group of the guanine residue. The protected nucleosides are useful starting materials for the synthesis of oligoribonucleotides. The 3, 4-dimethoxybenzyl group was removed rapidly ...