Computational predictions of binding affinities to dihydrofolate reductase: synthesis and biological evaluation of methotrexate analogues

M Graffner-Nordberg, J Marelius…

Index: Journal of Medicinal Chemistry, , vol. 43, # 21 p. 3852 - 3861

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Citation Number: 33

Abstract

... Journal of Medicinal Chemistry. ... AstraZeneca R&D Lund, SE-221 87 Lund, Sweden; Department of Pharmaceutical Microbiology, Uppsala Biomedical Center, Uppsala University, Box 581, SE-751 23 Uppsala, Sweden; and Department of Internal Medicine, Lund University ...

Design, synthesis, and proposed active site binding analysis...

[Adlington; Baldwin; Becker; Chen; Cheng; Cooper; Hermann; Howe; McCoull; McNulty; Neubauer; Pritchard Journal of Medicinal Chemistry, 2001 , vol. 44, # 10 p. 1491 - 1508]

Design, synthesis, and proposed active site binding analysis...

[Journal of Medicinal Chemistry, , vol. 44, # 10 p. 1491 - 1508]

Development of amidine-based sphingosine kinase 1 nanomolar ...

[Kennedy, Andrew J.; Mathews, Thomas P.; Kharel, Yugesh; Field, Saundra D.; Moyer, Morgan L.; East, James E.; Houck, Joseph D.; Lynch, Kevin R.; MacDonald, Timothy L. Journal of Medicinal Chemistry, 2011 , vol. 54, # 10 p. 3524 - 3548]