Synthesis

Reductive N-monoalkylation of primary aromatic amines

G Verardo, AG Giumanini, P Strazzolini, M Poiana

Index: Verardo; Giumanini; Strazzolini; Poiana Synthesis, 1993 , # 1 p. 121 - 125

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Citation Number: 59

Abstract

Primary aromatic amines 1 with a variety of ring substituents are easily converted to their N- monoalkyl derivatives 3 by a simple variation of the sodium borohydride/sulfuric acid/carbonyl compound procedure previously described for their N-perrnethylations. The procedure is suitable for the or-monodeuterium labelling of the new N-substituent.

~77%

~79%

~84%

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