Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation

…, T Endo, T Kanda, H Nakamura, S Yamasaki…

Index: Sakuma, Shogo; Endo, Tsuyoshi; Kanda, Takashi; Nakamura, Hideki; Yamasaki, Satomi; Yamakawa, Tomio Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 240 - 244

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Citation Number: 12

Abstract

We successfully synthesized a novel peroxisome proliferator-activated receptor (PPAR) δ selective agonist, namely, compound 20, with a characteristic benzisoxazole ring. Compound 20 exhibited potent human PPARδ transactivation activity and high δ selectivity. Further, it stimulated differentiation of primary oligodendrocyte precursor cells in vitro, indicating that it may be an effective drug in the treatment of demyelinating disorders such ...