Synthesis and pharmacological screening of a new series of 3-(4-anti-pyryl)-2-arylthiazolidin-4-ones

HA Al-Khamees, SM Bayomi, HA Kandil…

Index: Al-Khamees, Hamad A.; Bayomi, Said M.; Kandil, Hesham A.; El-Tahir, Kamal E. H. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 2 p. 103 - 106

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Citation Number: 22

Abstract

Abstract A series of 3-(4-antipyryl)-2-arylthiazolidin-4-one derivatives were synthesized and pharmacologically evaluated for antinociceptive, spasmolytic and cardiovascular activities. The presence of a methoxy-naphthyl or a substituted phenyl group in 2-position of the 4- thiazolidinone ring increased the antinociceptive and spasmolytic activities by 3–12-fold compared with antipyrine. The most potent were the o-methoxy naphthalene and the m- ...