An enantioselective intramolecular oxidative cyclization of 2-geranylphenols catalyzed by a Pd (II)-spiro bis (isoxazoline) complex is reported. The reaction proceeds in a 6-endo-trig manner to give chromene derivatives in reasonable yields and with moderate enantioselectivities. This transformation can be applied to a protecting-group-free total synthesis of naturally occurring cordiachromene.
