... solubility of valine in dioxane–H 2 SO 4 mixture during esterification with 2-methylpropene, and therefore to drastically decrease the reactor volume. ... 3. Deimer K.-H. In Houben-Weyl, 4th ed.; Wunsch, E., Ed.; Thieme: Stuttgart, 1975; Vol. ... Tetrahedron: Asymmetry, 10 (1999), pp. ...