Synthetic Communications®

Mild Approach to the Deprotection of Troc from Protected Amines Using Mischmetal and TMSCl

E Vellemäe, V Stepanov, U Mäeorg

Index: Vellemaee, Eerold; Stepanov, Vladimir; Maeorg, Uno Synthetic Communications, 2010 , vol. 40, # 22 p. 3397 - 3404

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Citation Number: 2

Abstract

The 2, 2, 2-trichloroethoxycarbonyl (Troc) protecting group was efficiently removed from Troc- protected aliphatic and aromatic amines and also some Troc, Tos-and Troc, Ac-protected amines using activated mischmetal (MM). All reactions were performed by refluxing in dry tetrahydrofuran under an argon atmosphere and gave moderate to excellent yields. Several new compounds were synthesized, and new data about reactivity of Troc group were ...