Compounds having a partial 2-pyridone structure or 3-pyridazinones can be selectively N- arylated with phenylboronic acids according to the procedure described by Chan and Lam. This procedure leads to N5-arylated imidazo [4, 5-c] pyridin-4-ones, precursors of potent factor Xa inhibitors. In addition, the synthesis of N-aryl substituted pyrrole-and indole-2- carboxylic acid esters is described. In the indole series this procedure offers a flexible ...
