Tetrahedron letters

A new strategy for the synthesis of β-benzylmercaptoethylamine derivatives

S Ghosh, GP Tochtrop

Index: Ghosh, Subrata; Tochtrop, Gregory P. Tetrahedron Letters, 2009 , vol. 50, # 15 p. 1723 - 1726

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Citation Number: 8

Abstract

Here, we describe a new experimental approach to the synthesis of the β- benzylmercaptoethylamine functionality, and illustrate its synthetic utility in multi-component reactions. Although prevalent in modern organic synthesis, no general methods have been described for this functionality. Using a carefully developed LiOH–water–ethanol reaction mixture, we were able to produce a diverse collection of β-benzylmercaptoethylamines ...