Synthesis and structure–activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents

…, L Chupak, M Dermyer, Q Ding, K Gavardinas…

Index: Vara Prasad; Boyer, Frederick E.; Chupak, Lou; Dermyer, Michael; Ding, Qizhu; Gavardinas; Hagen, Susan E.; Huband, Michael D.; Jiao, Wenhua; Kaneko, Takushi; Maiti, Samarendra N.; Melnick, Michael; Romero, Karina; Patterson; Wu, Xiujuan Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5392 - 5397

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Citation Number: 20

Abstract

... Scheme 4. Reagents: (a) sulfuric acid, MeOH; (b) appropriately substituted 1-iodo- or 1-bromo-3-nitrobenzene, Pd(OAc) 2 , triphenylphosphine, CuI, diethylamine, DMF; (c) 10% Pd/C, H 2 , MeOH; (d) ethyl chloroformate, diisopropylamine, CH 2 Cl 2 ; (e) 2 N LiOH, MeOH, THF; (f) P = Q = R = H: polyphosphoric acid, toluene, Celite; others: phosphorus pentoxide, methanesulfonic acid; (g) lithium tert-butoxide in hexanes, DMF. ... MIC (μg/mL), E. f. MIC (μg/mL). ...