Studies on the synthesis of chemotherapeutics. 12. Synthesis and antitumor activity of N-phthalidyl-5-fluorouracil derivatives

T Kametani, K Kigasawa, M Hiiragi…

Index: Kametani, Tetsuji; Kigasawa, Kazuo; Hiiragi, Mineharu; Wakisaka, Kikuo; Nakazato, Kikuo; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1219 - 1222

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Citation Number: 16

Abstract

Several N-phthalidyl-5-fluorouracil derivatives were synthesized for preliminary antitumor evaluation. Nl-Phthalidyland N3-phthalidyl-5-fluorouracils (6 and 10) showed a significant antitumor activity against experimental solid tumors with a good blood level of 5-fluorouracil in mice, even for oral administration.