Monatshefte für Chemie-Chemical Monthly

Lewis acid catalyst free synthesis of substituted imidazoles in 2, 2, 2-trifluoroethanol

S Khaksar, M Alipour

Index: Khaksar, Samad; Alipour, Mandana Monatshefte fur Chemie, 2013 , vol. 144, # 3 p. 395 - 398

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Citation Number: 10

Abstract

Abstract A simple, inexpensive, environmentally friendly, and efficient route for the synthesis of highly substituted imidazoles by the condensation of 1, 2-dicarbonyl compounds, aldehydes, and ammonium acetate using 2, 2, 2-trifluoroethanol as a solvent is described. The solvent can be readily separated from reaction products and recovered in excellent purity for direct reuse. Graphical abstract

89-98-5

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