Synthesis and anticancer activity evaluation of 2 (4-alkoxyphenyl) cyclopropyl hydrazides and triazolo phthalazines

…, M Baltas, D Lamoral-Theys, C Bruyère, R Kiss…

Index: De, Prithwiraj; Baltas, Michel; Lamoral-Theys, Delphine; Bruyere, Celine; Kiss, Robert; Bedos-Belval, Florence; Saffon, Nathalie Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 7 p. 2537 - 2548

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Citation Number: 22

Abstract

A series of new 2 (4-alkoxyphenyl) cyclopropyl hydrazide-and triazolo-derivatives were synthesized starting from 4-hydroxycinnamic acid (1) in a clean, mild, efficient and straightforward synthetic protocol. These compounds consisting of different alkoxy substitution, phenylcyclopropyl backbone and different heterocyclic groups were evaluated for in vitro anticancer activity against 4 cell lines displaying certain levels of resistance to ...