Supported TBD-assisted solution phase diversification of formyl-aza-heterocycles through alkylation-knoevenagel one pot sequences

A El Maatougui, A Crespo, A MS Silva…

Index: Maatougui, Abdelaziz El; Crespo, Abel; Silva, Artur M.S.; Coelho, Alberto Combinatorial Chemistry and High Throughput Screening, 2011 , vol. 14, # 7 p. 570 - 582

Full Text: HTML

Citation Number: 1

Abstract

An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements.

Regioselective Alkylation of 2-Alkyl-5, 6, 7, 8-tetrahydro-3...

[Sonegawa, Motoharu; Yokota, Masayuki; Tomiyama, Hiroshi; Tomiyama, Tsuyoshi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 5 p. 706 - 710]

Synthesis of N1-Aryl-and N1-Benzyl Substituted Imidazole-4-a...

[Antonini, Ippolito; Cristalli, Gloria; Franchetti, Palmarisa; Grifantini, Mario; Martelli, Sante Synthesis, 1983 , # 1 p. 47 - 49]

Regiochemistry of N??substitution of some 4 (5)??substituted...

[Oresmaa, Larisa; Taberman, Helena; Haukka, Matti; Vainiotalo, Pirjo; Aulaskari, Paula Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 6 p. 1445 - 1451]