Synthesis of linear tripeptides for right-hand segments of complestatin

…, A Akiba, S Arima, C Okada, K Yoshida, F Itou…

Index: Yamada, Yaeko; Akiba, Ai; Arima, Shiho; Okada, Chiharu; Yoshida, Kiminari; Itou, Fumihiro; Kai, Toshitsugu; Satou, Toshiko; Takeda, Kazuyoshi; Harigaya, Yoshihiro Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 10 p. 1277 - 1290

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Citation Number: 23

Abstract

This paper concerns a synthetic study of the right-hand segment of complestatin, an inhibitor of gp120-CD4 receptor. The effective synthesis of four important precursors for the right- hand segment of complestatin is described. Two of them are the precursor tripeptides for macrolactamization to the right-hand segment of complestatin at the last step and the other two are the precursor tripeptides for ring-closing reaction using Suzuki and Stille coupling, ...