Tetrahedron Letters

Synthesis of 2-methoxy-2-methyl-3-{6-[2-(5-methyl-2-phenyl-1, 3-oxazol-4-yl) ethoxy] pyridin-3-yl} propanoic acid, a dual PPARα/γ agonist

PS Humphries, QQT Do, DM Wilhite

Index: Humphries, Paul S.; Do, Quyen-Quyen T.; Wilhite, David M. Tetrahedron Letters, 2009 , vol. 50, # 16 p. 1765 - 1767

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Citation Number: 8

Abstract

As part of an ongoing PPAR drug discovery program in our laboratories, we originally synthesized racemic 1 and showed it to be of further interest to the team. 5 Chiral supercritical fluid chromatography (SFC) separation was performed on the racemic material, and the two enantiomers were isolated in >95% ee. 6 It was quickly established that the majority of the in vitro activity resided in the first eluting enantiomer 2 (Fig. 1). ... Racemic lead 1 and enantiomerically pure 2. Racemic ...