New carboxyalkyl compounds derived from Phe-Leu and Phe-Ala were synthesized and checked as inhibitors of “enkephalinase”, a metalloendopeptidase cleaving the Gly-Phe4 bond of enkephalins from mouse striatal membranes. Differential recognition of both brain enkephalinase and angiotensin-converting enzyme (ACE) catalytic sites by these carboxylalkyl compounds lead to potent (KI= 0.5 pM), competitive and selective inhibitors ...
![N-[(RS)-2-carbethoxy-3-phenylpropanoyl]-L-leucine Structure](https://image.chemsrc.com/caspic/079/83588-05-0.png)
