Synthesis of pyrrolo [2, 3-d] pyrimidine derivatives and their antiproliferative activity against melanoma cell line

MH Jung, H Kim, WK Choi, MI El-Gamal, JH Park…

Index: Jung, Myung-Ho; Kim, Hwan; Choi, Won-Kyoung; El-Gamal, Mohammed I.; Park, Jin-Hun; Yoo, Kyung Ho; Sim, Tae Bo; Lee, So Ha; Baek, Daejin; Hah, Jung-Mi; Cho, Jung-Hyuck; Oh, Chang-Hyun Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6538 - 6543

Full Text: HTML

Citation Number: 37

Abstract

Synthesis of a new series of diarylureas and amides having pyrrolo [2, 3-d] pyrimidine scaffold is described. Their in vitro antiproliferative activities against A375 human melanoma cell line and HS 27 fibroblast cell line were tested and the effect of substituents on pyrrolo [2, 3-d] pyrimidine was investigated. The newly synthesized compounds, except N-acetyl derivatives (Id, Ie, and Im), generally showed superior or similar activity against A375 to ...