Hindered dialkylamino nucleoside phosphite reagents in the synthesis of two DNA 51-mers

…, EJ Wykes, SB Holder, GR Galluppi

Index: Adams, Steven P.; Kavka, Kamila S.; Wykes, Evan J.; Holder, Sarah B.; Galluppi, Gerald R. Journal of the American Chemical Society, 1983 , vol. 105, # 3 p. 661 - 663

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Citation Number: 342

Abstract

DMT-dAbz 45> 96d DMT-dCbz 12 30> 96d DMT-dCtol-120c DMT-dGib 48> 96d DMT-dT 144-144'> 96d a Stability determined by disappearance of phosphite peaks in the,'P NMR spectrum;-0.1 M solutions in acetonitrile. The values obtained vary somewhat between preparations and should be used for comparison. Values in this series vary, but all are less stable than their ethyl counterparts by a factor of 2-4. A small amount of precipitate formed. ...