Synthesis and cytotoxicity evaluation of biaryl-based chalcones and their potential in TNFα-induced nuclear factor-κB activation inhibition

…, W Shao, B Zhou, L Lin, Z Luo, R Huang, J Du…

Index: Zuo, Yinglin; Yu, Yi; Wang, Shuni; Shao, Weiyan; Zhou, Binhua; Lin, Li; Luo, Zhuoyu; Huang, Ruogu; Du, Jun; Bu, Xianzhang European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 393 - 404

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Citation Number: 22

Abstract

A series of biaryl-based chalcones were designed as a combination of the natural chalcone and biphenyl moieties, and synthesized by two step chemistry involving Knoevenagel reaction and microwave assistant Suzuki coupling. Sulforhodamine B (SRB) assay was performed to evaluate the cell viability inhibitory abilities of these compounds against five cancer cell lines (A549, CNE2, SW480, MCF-7, and HepG2) from different tissues. Their ...