Azacycloalkanes XXX. Pyrrolo [1, 2-a] pyrazines with variable degrees of pyrazine ring saturation and their hypotensive activity

VP Peresada, OS Medvedev, AM Likhosherstov…

Index: Peresada, V. P.; Medvedev, O. S.; Likhosherstov, A. M.; Skoldinov, A. P. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 9 p. 619 - 624 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 9 p. 1054 - 1059

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Abstract

In order to obtain pyrrolo [1, 2-a] pyrazines of II in the form of the bicyclic compound la, we examined various versions of dehydrogenation. When Ia is heated in xylene with phenanthrenequinone, chloranyl or 2, 3-dichloro-5-dicyanobenzo-l, 4-quinone, intensive resinification takes place which prevents the separation of the reaction products. Dehydrogenation of Ia in the presence of Pd/C resulted in a IIa yield of 63%[5]. In ...