Design, synthesis and structure–activity relationship of novel RXR-selective modulators

…, DA Mais, CM Mapes, A Reifel-Miller, D Rungta…

Index: Michellys, Pierre-Yves; D'Arrigo, Jennifer; Grese, Timothy A.; Karanewsky, Donald S.; Leibowitz, Mark D.; Mais, Dale A.; Mapes, Christopher M.; Reifel-Miller, Anne; Rungta, Deepa; Boehm, Marcus F. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1593 - 1598

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Citation Number: 24

Abstract

Retinoids play a major role in a wide variety of biological functions, such as cell differentiation, proliferation and embryonic development in vertebrates. 1 All-trans-retinoid acid (ATRA, Fig. 1), 13-cis-retinoid acid (13-cis-RA, Fig. 1), 9-cis-retinoid acid (9-cis-RA, Panretin®, Fig. 1) and more recently the RXR selective LGD1069 (Targretin®, Fig. 1), have been administered for treatment of numerous skin diseases like psoriasis, acne, Karposi's ...