Fmoc??Protected Altritol Phosphoramidite Building Blocks and Their Application in the Synthesis of Altritol Nucleic Acids (ANAs)

…, A Van Aerschot, P Herdewijn

Index: Abramov, Mikhail; Schepers, Guy; Van Aerschot, Arthur; Herdewijn, Piet European Journal of Organic Chemistry, 2007 , # 9 p. 1446 - 1456

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Citation Number: 6

Abstract

Abstract Fmoc-protected altritol nucleoside phosphoramidite building blocks with adenine, guanine, thymine, uracil, cytosine and 5-methylcytosine as bases have been synthesized. These building blocks were used for the synthesis of altritol nucleic acid (ANA) and chimeric ANA-RNA oligonucleotides. Whilst the yields of oligonucleotides were lower than those obtained with 3′-O-benzoyl-protected altritol building blocks, the excellent compatibility ...