Till now, no multivalent derivatives of the/3-lactam antibiotics have been synthesized. In continuation of our work in the synthesis of podand molecules6), the present paper describes the preparation of certain podand-type trimers of cephalosporin antibiotics (Scheme 1). Asthe central block of the target trimers the tricarboxylic acid 3 was employed, which was obtained by the alkylation of phloroglucinol (1) with methyl bromoacetate and ...
