Selection, synthesis, and structure–activity relationship of tetrahydropyrido [4, 3-d] pyrimidine-2, 4-diones as human GnRH receptor antagonists

…, M Feher, NJ Ashweek, CJ Loweth, JK Rueter…

Index: Lanier, Marion C.; Feher, Miklos; Ashweek, Neil J.; Loweth, Colin J.; Rueter, Jaimie K.; Slee, Deborah H.; Williams, John P.; Zhu, Yun-Fei; Sullivan, Susan K.; Brown, Michael S. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 16 p. 5590 - 5603

Full Text: HTML

Citation Number: 27

Abstract

The present article describes a selection of a new class of small molecule antagonists for the h-GnRH receptor, their preparation, and evaluation in vitro. Three computational methods were combined into a consensus score, to rank order virtual templates. The top 5% of templates were further evaluated in silico and assessed for novelty and synthetic accessibility. The tetrahydropyrido [4, 3-d] pyrimidine-2, 4-dione core was selected for ...