Potential photoaffinity labels for tubulin. synthesis and evaluation of diazocyclohexadienone and azide analogs of colchicine, combretastatin, and 3, 4, 5- …

JD Olszewski, M Marshalla, M Sabat…

Index: Olszewski; Marshalla; Sabat; Sundberg Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4285 - 4296

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Citation Number: 33

Abstract

Colchicine has a unique place in the study of antimi-totic substances which act by affecting the tubulin assembly-disassembly process.'Indeed, the colchicinebinding property of tubulin was the basis of its initial isolation. 2 Subsequently, many other naturally-occuning and synthetic compounds which bind at the “colchicine site” and inhibit tubulin assembly have been identified. One subset of these has in common the trimethoxybenzene ring found in ...