BN 80245: an E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities

O Lavergne, L Lesueur-Ginot, FP Rodas…

Index: Lavergne, Olivier; Lesueur-Ginot, Laurence; Rodas, Francesc Pla; Bigg, Dennis C. H. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2235 - 2238

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Citation Number: 113

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The crucial E-ring of camptothecin has been modified to afford the homologous β-hydroxylactone derivative BN 80245. This compound, which is more stable than camptothecin, remains a potent inhibitor of both cell growth and topoisomerase I. ... The crucial E-ring of camptothecin ...