Synthesis

Synthesis of Venlafaxine from azadiene via a Hetero-Diels-Alder approach: New microwave-assisted transketalization and hydroxymethylation reactions

M Panunzio, E Bandini, A D'Aurizio, Z Xia, X Mu

Index: Panunzio, Mauro; Bandini, Elisa; D'Aurizio, Antonio; Xia, Zhining; Mu, Xiaojing Synthesis, 2008 , # 11 p. 1753 - 1756

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Citation Number: 10

Abstract

The necessary [4+2] HDA reaction was next attempted taking advantage of our recent procedure for the preparation of 1,3-perhydrooxazin-4-ones by EuFod [europium(III) tris(1,1,2,2,3,3-heptafluoro -7,7-dimethyl-4,6-octanedionate]-catalyzed microwave-assisted organic synthesis (MAOS). [8] Accordingly, reaction of the azadiene 4 with dienophile cyclohexanone (5) was performed, using EuFod (0.05%) as catalyst and chlorobenzene as solvent under ...