Aplysia californica mediated cyclisation of novel 3′-modified NAD+ analogues: a role for hydrogen bonding in the recognition of cyclic adenosine 5′-diphosphate …

CJW Mort, ME Migaud, A Galione, BVL Potter

Index: Mort, Christopher J. W.; Migaud, Marie E.; Galione, Antony; Potter, Barry V. L. Bioorganic and Medicinal Chemistry, 2004 ,  vol. 12,  # 2  p. 475 - 487

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Citation Number: 11

Abstract

Cyclic ADP-ribose mobilizes intracellular Ca2+ in a variety of cells. To elucidate the nature of the interaction between the C3′ substituent of cADP-ribose and the cADPR receptor, three analogues of NAD+ modified in the adenosine ribase (xyloNAD+ 3′ F-xyloNAD+ and 3′ F-NAD+ were chemically synthesised from d-xylose and adenine starting materials. 3′ F-NAD+ was readily converted to cyclic 3′ F-ADP ribose by the action of the cyclase ...