Antitussive effects of azepino [2, 1-b] quinazolones

…, S Sapra, A Garg, S Kumar, P Sharma, R Goyal…

Index: Nepali, Kunal; Bande, Mukunda S.; Sapra, Sameer; Garg, Atul; Kumar, Sunil; Sharma, Punita; Goyal, Rohit; Satti, Naresh Kumar; Suri, Om Parkash; Dhar, Kanaya Lal Medicinal Chemistry Research, 2012 ,  vol. 21,  # 7  p. 1271 - 1277

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Citation Number: 8

Abstract

Abstract A series of azepino [2, 1-b] quinazolones (C-1–C-16) have been synthesized and evaluated for their antitussive activity using citric acid-induced cough model in Guinea pigs. The compounds C-1–C-16 caused notable decrease in cough frequency and increase in cough latency induced by citric acid. C-3 [2, 4-dibromo-7, 8, 9, 10-tetrahydroazepino [2, 1-b] quinazolin-12 (6H)-one] showed notable antitussive effect as compared with codeine (10 ...