Structure-activity studies of trichothecenes: cytotoxicity of analogs and reaction products derived from T-2 toxin and neosolaniol

DW Anderson, RM Black, CG Lee…

Index: Anderson, D. W.; Black, R. M.; Lee, C. G.; Pottage, C.; Rickard, R. L.; et al. Journal of Medicinal Chemistry, 1989 ,  vol. 32,  # 3  p. 555 - 562

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Citation Number: 34

Abstract

Forty-two analogues and reaction products derived from T-2 toxin or neosolaniol were assayed for their cytotoxicity to cultured mouse lymphoma cells. Structureactivity relationships confiimed the stereospecific nature of the cytotoxic action of T-2. Cytotoxicity was particularly susceptible to changes at C3, C4, C9, and C10 but was relatively unaffected by changes at C8, which appears to represent a region of steric tolerance in the ...