Heterocyclic quinones. XIII. Dimerization in the series of 5, 8-quinazolinediones: Synthesis and antitumor effects of bis (4-amino-5, 8-quinazolinediones).

…, M BARON, P GEBEL-SERVOLLES, J DELIC…

Index: Giorgi-Renault; Renault; Baron; Gebel-Servolles; Delic; Cros; Paoletti Chemical and Pharmaceutical Bulletin, 1988 ,  vol. 36,  # 10  p. 3933 - 3947

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Citation Number: 10

Abstract

With the aim of obtaining new antitumor drugs more active than previously described 5, 8- quinazolinediones, a series of dimers of 5, 8-quinazolinediones linked in the 4-position by a simple or a substituted χ, ω-diaminopolymethylenic chain was studied. The structure-activity relationships of these compounds are discussed as functions of the length of the chain, presence or absence of other functional groups, nature of these functional groups, ...