Chloramphenicol (Chloromycetin). 1 V. Synthesis

J Controulis, MC Rebstock…

Index: Controulis; Rebstock; Crooks Journal of the American Chemical Society, 1949 ,  vol. 71, p. 2463            

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Citation Number: 151

Abstract

H NHCOCHCI:! the final proof of structure resting upon synthesis. In this paper we wish to report the synthesis of this structure and the identification of one of the isomeric forms with the antibiotic as produced by fermentation procedures. Cherbuliez, Neumeier and Lozeron2 have reported the preparation of compounds related to ephedrine, hearing a hydroxyl group on the terminal carbon of the side-chain and derivatives of this structure by reaction of 2- ...