Potassium phenoxymethylpenicillinate (VIII), synthesized totally in a series of reactions from D-penicillamine (0-11) and t-butyl phthalimidomalonaldehydate (I), has been shown to be identical to natural penicillin V (potassum salt) in physical and biological properties. In the key step, the monopotassium salt of the penicilloic acid (D-CY-VII) wdS cyclized by means of N, N'-dicyclohexylcarbodiimide. A similar series of reactions starting with DL-penicillamine ...
![(4S)-2t-[(R)-tert-butoxycarbonyl-(2-phenoxy-acetylamino)-methyl]-5,5-dimethyl-thiazolidine-4r-carboxylic acid Structure](https://image.chemsrc.com/caspic/415/1057-37-0.png)
