Identification of a novel non-carbohydrate molecule that binds to the ribosomal A-site RNA

…, M Motamed, KB Turner, MSK Choi, J Ramnauth…

Index: Maddaford, Shawn P.; Motamed, Mina; Turner, Kevin B.; Choi, Min Soo K.; Ramnauth, Jailall; Rakhit, Suman; Hudgins, Robert R.; Fabris, Daniele; Johnson, Philip E. Bioorganic and Medicinal Chemistry Letters, 2004 ,  vol. 14,  # 24  p. 5987 - 5990

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Citation Number: 14

Abstract

We report the identification of a novel compound that binds to the Escherichia coli 16S ribosomal A-site. Binding by the compound was observed using nuclear magnetic resonance and mass spectrometry techniques. We show that the compound binds in the same position in the A-site RNA as occupied by the aminoglycoside class of antibiotics.