Journal of medicinal chemistry

Novel Polycyclic Heterocycles. II. Derivatives of 5, 11-Dihydrodibenz [b, e][1, 4] oxazepine1

HL Yale, F Sowinski

Index: Yale,H.L.; Sowinski,F. J. Med. Chem., 1964 ,  vol. 7, p. 609 - 614

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Citation Number: 16

Abstract

(VI).. ilkylation of I and 1-1 with dialkylaniinoalkyl chlorides was best carried out with sodium hydride in dirnet. hy1 sulfoxide. In addition, I and VI were allowed to react wit, h 3- chloropropionyl chloride and the resulting 5-(~-chloropropiollyl) derivatives convert, ed to 5- (3-monoalkyl-and 3-dialkylaminoacyl) derivatives. I and phosgene gave the 5-carbonyl chloride, and this derivative with dialkylamino alcohols and dialkylaminoalkylamines gave ...