4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor

…, Y Okuma, Y Nomura, Y Murakami, H Hamana

Index: Mimori, Seisuke; Okuma, Yasunobu; Kaneko, Masayuki; Kawada, Koichi; Nomura, Yasuyuki; Murakami, Yasuoki; Hamana, Hiroshi Chemistry Letters, 2013 ,  vol. 42,  # 9  p. 1051 - 1052

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Citation Number: 22

Abstract

Abstract This letter describes the mechanism behind the protective effect of 4-phenylbutyric acid (4-PBA) against endoplasmic reticulum (ER) stress-induced neuronal cell death using three simple 4-(p-substituted phenyl) butyric acids (4-PBA derivatives). Their relative human histone deacetylase (HDAC) inhibitory activities were consistent with a structural model of their binding to HDAC7, and their ability to suppress neuronal cell death and activity of ...