Several 4-substituted 1-acylpiperazines, obtained by molecular simplification of 4- substituted 1, 4-diazabicyclo [4.3. 0] nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoidance test, to evaluate their nootropic activity. The results show that, apparently, an N-acylpiperazine group can mimic the 2-pyrrolidinone ring of 1, 4- diazabicyclo [4.3. 0] nonan-9-one, as the compounds of the new series maintain high ...
