Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease

…, F Narjes, S Malancona, VG Matassa, C Gardelli

Index: Nizi, Emanuela; Koch, Uwe; Ontoria, Jesus M.; Marchetti, Antonella; Narjes, Frank; Malancona, Savina; Matassa, Victor G.; Gardelli, Cristina Bioorganic and Medicinal Chemistry Letters, 2004 ,  vol. 14,  # 9  p. 2151 - 2154

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Citation Number: 19

Abstract

The N-terminal aminoacid of phenethylamide tripeptide inhibitors of the hepatitis C virus NS3 protease can be replaced with an α-hydroxy acid to obtain more 'drug like'inhibitors with low micromolar activity. The preferred S-configuration of the capping residue can be explained by molecular modeling studies.