... Organic Process Research & ... A key portion of the development of a commercial synthesis is the identification of all impurities in the drug substance and later intermediates. ... The first method attempted was to examine all isolated process intermediates for an “M + 14” impurity. ...
![4,6-dimethoxy-1,3,5-triazin-2-yl 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate Structure](https://image.chemsrc.com/caspic/218/1209465-70-2.png)
![PEMETREXED DIETHYL ESTER (L-GLUTAMIC ACID, N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-, 1,5-DIETHYL ESTER ) Structure](https://image.chemsrc.com/caspic/145/146943-43-3.png)
![4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Structure](https://image.chemsrc.com/caspic/125/137281-39-1.png)
![Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 4-methylbenzenesulfonate Structure](https://image.chemsrc.com/caspic/398/165049-28-5.png)